(1′S,6′S,8′S,9′R)-9′-Bromo-12′-oxaspiro[1,3-dioxolane-2,4′-tricyclo[6.3.1.01,6]dodecane]
نویسندگان
چکیده
In an endeavor directed towards the construction of the oxabicyclic[3.2.1]octane segment present in the bioactive natural products of cortistatins and icetexanes genre, the title compound, C(13)H(19)BrO(3), was synthesized from (4aR,9aS)-1,3,4,4a,5,6,9,9a-octa-hydro-spiro-[benzo[7]annulene-2,2'-[1,3]dioxolane]-4a-ol via a transannular bromo-etherification protocol. The six-membered ring adopts a twist-boat conformation, while the fused cycloheptane ring adopts a chair conformation. The crystal packing is effected through two distinct inter-molecular C-H⋯O hydrogen-bond patterns and mol-ecules are arranged to define an inter-esting motif along the b axis.
منابع مشابه
anti-1′,6′,7′,8′,9′,14′,15′,16′-Octachlorodispiro[1,3-dioxolane-2,17′-pentacyclo[12.2.1.16,9.02,13.05,10]octadecane-18′,2′′-1,3-dioxolane]-7′,15′-diene
The title compound, C(22)H(20)Cl(8)O(4), was prepared as part of the synthesis of precursors for the preparation of fluorinated mol-ecular tweezers. The mol-ecule sits on an inversion center, thus requiring that the cyclo-octane ring adopt a chair conformation.
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